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Researchers have been trying to develop molecules called antagonists to block CB1's function in conditions in which the receptor is overactive, like obesity, but until now the use of the antagonists has been thwarted by psychiatric side effects including mood disorders and anxiety arising from their activity in the brain

PLoS One 13(4):e0195925 Mulder HA, Stewart JB, Blue IP, Krakowiak RI, Patterson JL, Karin KN et al (2020) Characterization of E-cigarette coil temperature and toxic metal analysis by infrared temperature sensing and scanning electron microscopy - energy-dispersive X-ray

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And the government's drugs commissioner estimates that around 110,000 people die each year of smoking-related illnesses